Executive Director, Pharmacokinetics and Drug Metabolism

Company: Initial Therapeutics, Inc.
Location: Thousand Oaks
Posted on: February 1, 2025

Job Description:

HOW MIGHT YOU DEFY IMAGINATION?At Amgen, every challenge is an opportunity. And every opportunity brings the potential to change lives. Our shared mission to serve patients has driven our status as one of the world's preeminent biotechnology companies, reaching over 10 million patients worldwide. Leverage your high-level expertise to lead and forge partnerships that advance the biotechnical and biopharmaceutical science that can turn the tide of serious, life-interrupting illnesses.Executive Director, Pharmacokinetics and Drug MetabolismWhat you will doIn this vital role as the Executive Director, Pharmacokinetics and Drug Metabolism (PKDM), you will be the leader of PKDM Analytical Sciences, Data Sciences, and Biomarker team interfacing and building partnerships across Research and Development to PKDM.This role will report into the Vice President of PKDM. This role is located within the United States, in Thousand Oaks, CA with expected travel to South San Francisco at least quarterly.Responsibilities:

• Oversee analytical, data, and biomarker sciences innovation impacting Research & Development.
• Develop strategy and goals to meet Research and Development business deliverables, affecting decision making and advancing Amgen's pipeline.
• Establish and execute strategic plans and scientific goals for non-regulated bioanalytical sciences, data sciences, and biomarker strategies in collaboration with key stakeholders across research, aiding in the transition to development.
• Drive strategic direction for PKDM analytical and data sciences, progressing the Research portfolio from new targets through IND, focusing on developing and implementing innovative workflows into reverse translation.
• Ensure quality, continuity, and impact of non-clinical analytical results from research into clinical development.
• Lead teams responsible for bioanalytical, biomarkers, and data sciences deliverables.
• Develop scientific, workflow, and process improvements to meet current and future innovation demand in translational sciences for Research.
• Influence and contribute to PKDM departmental goals, operations, and deliverables.
• Responsible for decision making on budget, resources, instruments, and staff scope within the function to deliver on Research & Development business goals successfully.
• Provide insights and advice to VP PDKM on strategic directions with 3-5 year-time horizons.
• Deliver on non-regulated bioanalytical goals with quality and compliance to advance the Research and Development Pipeline.
• Influence Research level strategy and goals related to Analytics, Artificial Intelligence, and Translational Pharmacology, identifying opportunities to accelerate innovation.
• Develop and implement a strategy for resourcing the analytics group and delivering on Research Goals.
• Address key Research & Development portfolio risks regarding non-regulated bio analytics and data sciences.
• Act as PKDM's liaison to key partners, including Precision Medicine, Translational Safety and Bioanalytical, Center for Research Acceleration by Digital Innovation, Amgen Technology and Medical Organizations, Digital, Technology & Innovation, Clinical Biomarkers, and Therapeutic Area Leaders.
• Represent Amgen and PKDM externally in scientific and business-related organizations.
• Develop workflows and future directions for analytical and data sciences, focusing on internal strengths and externalization opportunities.
• Integrate analytical and biomarker data with digital tools into Artificial Intelligence/Machine Learning data initiatives across Research and Development.
• Develop a talent pipeline of high-caliber scientists in analytical and data sciences.What we expect of youThe candidate we seek is an experienced leader with the following qualifications.Basic Qualifications:
  • Doctorate degree & 6 years of Analytical Sciences/Pharmaceutical Sciences experience OR
  • Masters degree & 10 years of Analytical Sciences/Pharmaceutical Sciences experience OR
  • Bachelors degree & 12 years of Analytical Sciences/Pharmaceutical Sciences experience AND
  • 6 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources.Preferred Qualifications:
    • Ph.D. in Biochemistry and Analytical Sciences, Pharmaceutical Sciences, or related discipline.
    • 15+ years or more experience leading functions strategically and scientifically in analytical, data and biomarker sciences related research and innovation, preferably in the therapeutic areas of Cardiovascular and Metabolic, Inflammation, Oncology, and Rare Disease.
    • 10+ years or more industry experience, including 6 years of experience leading teams in research in the areas of Analytical Sciences and Biomarker research.
    • Strong understanding of Drug Discovery and Development with an emphasis in translational sciences as they relate to analytical sciences in pharmacokinetics and biomarkers.
    • Fundamental level of understanding for the application of artificial intelligence and data sciences.
    • Experience in departmental and organizational leadership including, but not limited to, managing teams, budgets and operations.
    • Strong track record of innovation impact internally and externally.People and Team Management
      • Manages and mentors staff to accomplish defined organizational goals and objectives.
      • Able to navigate and influence in a large global, matrixed organization.
      • Identifies and adapts to shifting priorities and competing demands.
      • Highly effective at leading and influencing internal and external stakeholders to achieve organizational goals.
      • Prioritizes DI&B principles in leadership style.They will also embody the Amgen leadership attributes which are:
        • Inspire: Create a connected, inclusive, and inspiring work environment that empowers talent to thrive.
        • Accelerate: Enable speed that matches the urgency of patient needs by encouraging progress over perfection.
        • Integrate: Connect the dots to amplify the collective power of Amgen to drive results for patients, staff, and shareholders.
        • Adapt: Lead through change by adapting to an ever-changing environment and defining a clear course of action to deliver results.What you can expect of usThe annual base salary range for this opportunity in the U.S. is $279,451 - $312,792.In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
          • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
          • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
          • Stock-based long-term incentives.
          • Award-winning time-off plans and bi-annual company-wide shutdowns.
          • Flexible work models, including remote work arrangements, where possible.Amgen's Commitment to Our StaffAt Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our people-first philosophy.We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.We equip all our staff members to live well-rounded, healthy lives. Most recently, Amgen added benefits for transgender employees and continues to pride itself on industry-leading, family-friendly offerings for families of all compositions.Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
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Keywords: Initial Therapeutics, Inc., Montebello , Executive Director, Pharmacokinetics and Drug Metabolism, Executive , Thousand Oaks, California